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Incidence of leukemia in the northwest of iran
Saeed Dastgiri1, Shahla Fozounkhah2, Somaiie Shokrgozar2
1Hematology & Oncology Research Centre and National Public Health Management Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Insights
This study documented leukemia epidemiology in Northwest Iran, finding higher incidence in Ardebil and a male-to-female ratio of 1.23. Myeloid leukemia was most common, highlighting the need for regional health registries and targeted control strategies.
Area of Science:
- Hematology
- Epidemiology
- Oncology
Background:
- Leukemia, a cancer of blood or bone marrow, involves an abnormal increase in white blood cells.
- It ranks as the sixth most common malignancy affecting both genders.
- This study focuses on the epidemiological characteristics of leukemia in Northwest Iran.
Purpose of the Study:
- To document the epidemiological features of leukemia in Northwest Iran.
- To provide baseline data for establishing a population-based registry of hematologic disorders.
- To inform the development of effective control strategies for high-risk groups.
Main Methods:
- A cross-sectional study involving 669 leukemia cases from Tabriz and Ardebil (2003-2006).
- Classification of patients using the ICD-10 coding system (C91-C95, C77, C42).
- Calculation of 95% confidence intervals to assess statistical significance.
Main Results:
- Annual leukemia incidence was 3.7 per 100,000 in Tabriz and 4.9 per 100,000 in Ardebil.
- The overall case fatality rate was 13.5%, with a male-to-female sex ratio of 1.23.
- Myeloid leukemia (C92) and Hematopoetic and Reticuloendothelial system (C42) constituted over 47% of cases.
Conclusions:
- The study provides essential baseline data for a potential hematologic disorders registry in Northwest Iran.
- Further research is necessary to develop targeted control strategies for leukemia.
- Findings underscore the importance of regional data collection for public health planning.
Background:
Leukemia is cancer of the blood or bone marrow, characterized by an unusual increase in white blood cells. It is the sixth most common malignancy in the country in both males and females. The aim of this study was to document some epidemiological features of leukemia in the Northwest of Iran.
Methods:
The study subjects (n=669, including 377 males and 292 females) comprised all leukemia cases registered/notified to the clinical and pathology centers of Tabriz and Ardebil cities, from 2003 to 2006. All patients were classified using the ICD-10 based coding system (C91-C95, C77 and C42). Ninety-five percent confidence intervals were calculated to assess the statistical significance of the data.
Results:
Annual incidence of leukemia was 3.7 [95% CI: 3.3-4.0] and 4.9 [95% CI: 4.2-5.6] per 100 000 population in Tabriz and Ardebil, respectively, with an overall case fatality rate of 13.5 percent [95% CI: 10.8-16.0]. The sex ratio (male/female) was 1.23. Myeloid leukemia (C92) and Hematopoetic and Reticuloendothelial system (C42) accounted proportionally for more than 47 percent of cases in the region. Over the study period, the annual occurrence of leukemia in the region increased from 3.9 [95% CI: 3.4-4.5] to 4.1 [95% CI: 3.5-4.6] per 100 000 population (P>0.1).
Conclusions:
The data from this cross-sectional study of leukemia in the North-West of Iran may be used as the baseline information to establish a population-based registry of hema-tologic disorders in the area for health care and research purposes. However, more investiga-tions are needed to develop effective strategies to control the relevant disorders in high-risk groups.
