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Intestinal stem cell imaging in colorectal cancer screening
1Digestive Oncology Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences , Tehran, Iran.
Journal of Stem Cells & Regenerative Medicine
|April 3, 2014
Summary
Imaging abnormal intestinal stem cells could offer a new method for colorectal cancer (CRC) screening. This approach may detect early changes in stem cell compartments, aiding in CRC tumor initiation detection.
Area of Science:
- Oncology
- Gastroenterology
- Stem Cell Biology
Background:
- Colorectal cancer (CRC) is a leading cause of cancer death globally.
- While the adenoma-carcinoma progression is understood, tumor initiation mechanisms remain unclear.
- Murine studies suggest intestinal tumors arise from normal stem cells acquiring oncogenic mutations.
Purpose of the Study:
- To investigate the potential of imaging intestinal stem cell abnormalities for colorectal cancer screening.
- To explore the hypothesis that stem cell compartment abnormalities are early detectable phenotypic changes in tumorigenesis.
Main Methods:
- Review of murine studies on intestinal tumor origins.
- Conceptual integration of stem cell imaging into CRC screening strategies.
Main Results:
- Intestinal tumors appear to originate from normal intestinal stem cells.
- Abnormalities in the stem cell compartment may represent the earliest phenotypic changes in tumorigenesis.
Conclusions:
- Imaging the abnormal state of the intestinal stem cell compartment is a plausible strategy for CRC screening.
- This approach could potentially detect early, pre-cancerous changes in the intestinal stem cell compartment.
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