[Astromicin sulfate concentration in human prostatic tissue after an intramuscular injection]

The present study was undertaken to evaluate the penetration of astromicin sulfate into prostatic tissue. Twenty eight patients with benign prostatic hypertrophy entered the study. Astromicin sulfate was administered as an intramuscular injection in a dose of 200 mg one hour preoperatively. Blood samples were taken simultaneously with the tissue sampling at the transurethral resection of the prostate. The mean concentration of astromicin sulfate in prostatic tissue was 3.79 +/- 1.01 micrograms/g and that in serum was 10.25 +/- 2.70 micrograms/ml.