Lupus - the cold, hard facts
Related Experiment Video
Updated: May 1, 2026

The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
Published on: November 1, 2015
N W K Wong1, Vt-Y Ng2, S Ibrahim2
1Department of Medicine, McMaster University, Hamilton, Canada; Department of Medicine, University of Toronto, Toronto, Canada; Division of Rheumatology, Department of Medicine, University of Toronto, Toronto, Canada; and Toronto Western Hospital, University Health Network, Toronto, Canada newton.wong@medportal.ca.
Abstract:
Systemic lupus erythematosus (SLE) is a multisystem chronic disease with a multitude of clinical presentations. We review and synthesize how an environmental insult (exposure to extreme cold for a short duration) and endogenous (antiphospholipid antibody syndrome, SLE vasculitis) insults in a susceptible young female with lupus (peripheral arterial disease, smoking, SLE) led to a perfect storm resulting in catastrophic injuries (frostbite).
Related Concept Videos
Autoimmune Disorders
Concept and Mechanism of Autoimmune Diseases
The immune...
Rheumatic Heart Disease I: Introduction
Multiple Sclerosis l: Introduction
Nephrotic Syndrome I : Introduction
Nephrotic Syndrome II : Assessment and Medical Management
Factors Affecting Illness
For instance, risk factors are connected to illness,...

