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Updated: May 1, 2026

Analysis of Fecal Microbiota Dynamics in Lupus-Prone Mice Using a Simple, Cost-Effective DNA Isolation Method
Published on: May 2, 2022
Genome-wide genetic study in autoimmune disease-prone mice
Masaomi Obata1, Mareki Ohtsuji, Yukiyasu Iida
1Department of Bioengineering, Toin Human Science and Technology Center, Toin University of Yokohama, 1614 Kurogane-cho Aoba-ku, Yokohama, 225-8502, Japan.
Abstract:
Mouse models of autoimmune diseases provide invaluable insights into the cellular and molecular bases of autoimmunity. Genetic linkage studies focusing on their abnormal quantitative phenotypes in relation to the loss of self-tolerance will lead to the identification of polymorphic genes that play pivotal roles in the genetic predisposition to autoimmunity. In this chapter, we first overview the basic concepts in the statistical genetics and then provide guides to genotyping microsatellite DNA markers and to quantitative trait loci mapping using a MAPMAKER program.
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