Related Experiment Video
Updated: May 1, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
Published on: December 15, 2011
Eczema herpeticum in a wrestler
Renuka Shenoy1, Eliot Mostow, Gregory Cain
1*Northeast Ohio Medical University, Rootstown, Ohio; †Case Western Reserve University School of Medicine, Cleveland, Ohio; and ‡Department of Sports Medicine, Summa Health System, Akron, Ohio.
Eczema herpeticum (EH) is a disseminated skin infection caused by herpes simplex virus on compromised skin. Early antiviral treatment is crucial, especially in populations like wrestlers with atopic dermatitis, to manage this rapidly spreading condition.
Area of Science:
- Dermatology
- Infectious Diseases
- Virology
Background:
- Eczema herpeticum (EH) is a severe skin infection historically documented since 1887.
- It presents as a disseminated eruption of dome-shaped papules, often accompanied by systemic symptoms like fever and malaise.
- EH typically affects the trunk, head, and neck, frequently complicating pre-existing skin conditions such as atopic dermatitis.
Observation:
- The condition arises from a herpes simplex virus (HSV) infection superimposed on compromised skin.
- Atopic dermatitis is a prevalent skin condition in the general population.
- Herpes gladiatorum is a common HSV infection observed within the wrestling community.
Findings:
- The co-occurrence of atopic dermatitis and herpes gladiatorum significantly elevates the risk of developing eczema herpeticum.
- This synergistic risk highlights the vulnerability of athletes, particularly wrestlers, who often have atopic dermatitis.
Implications:
- Sports medicine physicians and dermatologists must recognize the heightened risk of EH in athletic populations, especially wrestlers.
- Prompt identification of EH signs and symptoms is critical for timely intervention.
- Rapid initiation of antiviral therapy is essential for managing this potentially severe and rapidly spreading infection.
Related Concept Videos
Skin Diseases and Disorders
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Acne Infection
Staphylococcal Skin Infections
Skin Cancer
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Allergic Reactions
Drug Toxicity: Allergic Reactions

