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Animal models in burn research.
A Abdullahi1, S Amini-Nik, M G Jeschke
1Division of Plastic Surgery, Department of Surgery, University of Toronto, Toronto, Canada, abdikarim.abdullahi@sunnybrook.ca.
Cellular and Molecular Life Sciences : CMLS
|April 10, 2014
Summary
This review evaluates animal models for burn injury research, focusing on skin healing in mice, rats, and pigs. Understanding model limitations is crucial for developing clinically relevant burn treatments.
Area of Science:
- Biomedical Engineering
- Translational Medicine
- Trauma Research
Background:
- Burn injury is a complex trauma affecting millions annually, causing multi-organ deficits.
- In vitro models are insufficient for studying burn pathophysiology due to its systemic nature.
- Animal models are essential for understanding burn injury and testing treatments.
Purpose of the Study:
- To review common animal models for burn injury research.
- To elucidate the advantages and limitations of these models for translational applications.
- To guide researchers in selecting appropriate models for burn research.
Main Methods:
- Focus on skin healing models in mice, rats, and pigs.
- Briefly discuss models for hypermetabolic burn characteristics.
- Analyze economic costs associated with different animal models.
Main Results:
- Mouse, rat, and pig models offer distinct advantages for studying burn-related skin healing.
- Specific models exist to investigate hypermetabolic states post-burn.
- Economic factors vary significantly between models, influencing research feasibility.
Conclusions:
- Selection of an appropriate animal model is critical for the success of burn research.
- Understanding model-specific benefits and drawbacks enhances translational relevance.
- Cost-effectiveness should be considered alongside scientific rigor when choosing a burn model.
