Related Experiment Videos
[Incidental prostatic carcinoma obtained from the tissue by transurethral resection]
M Masuda1, Y Ishibashi, H Fukuoka
1Department of Urology, Yokohama Minami Kyosai Hospital.
Hinyokika Kiyo. Acta Urologica Japonica
|March 1, 1989
Summary
Transurethral resection of benign prostatic hypertrophy incidentally found 8.2% of prostate cancer. Higher tumor chip counts correlated with poorly differentiated adenocarcinoma, suggesting a need for refined staging criteria.
Area of Science:
- Urology
- Oncology
- Pathology
Context:
- Transurethral resection of the prostate (TURP) is a common procedure for benign prostatic hyperplasia (BPH).
- Incidental prostate cancer detection during TURP presents diagnostic challenges.
- Histopathological analysis of resected tissue is crucial for diagnosis.
Purpose:
- To determine the incidence of incidental prostate carcinoma in patients undergoing TURP for BPH.
- To investigate the correlation between tumor chip quantity and histopathological features of incidental prostate cancer.
- To evaluate the relationship between tumor chip ratio and specific cancer grading.
Summary:
- A retrospective study of 461 patients undergoing TURP for BPH between 1982 and 1988 identified 38 cases (8.2%) of incidental prostate carcinoma.
- A higher number of tumor chips resected during TURP was associated with a decrease in well and moderately differentiated adenocarcinomas.
- Specifically, 70% of patients with over 11 tumor chips had poorly differentiated adenocarcinoma, and increasing tumor chip ratios correlated with higher rates of INF gamma.
Impact:
- Findings highlight the significance of histopathological examination of TURP specimens for incidental prostate cancer detection.
- The study suggests that tumor chip quantity and ratio may provide prognostic information.
- Establishes the need for uniform substaging criteria for incidental prostate carcinoma (Stage A) detected via TURP.