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Advances in cellular and tissue engineering using layer-by-layer assembly.

Anita Shukla1, Bethany Almeida

  • 1Center for Biomedical Engineering, Institute for Molecular and Nanoscale Innovation, School of Engineering, Brown University, Providence, RI, USA.

Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
|April 12, 2014
PubMed
Summary
This summary is machine-generated.

Layer-by-layer (LbL) assembly creates advanced multilayer films for cellular and tissue engineering. These adaptable biomaterials enhance cell behavior control and scaffold design for regenerative medicine and therapies.

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Area of Science:

  • Biomaterials Science
  • Cellular Engineering
  • Tissue Engineering

Background:

  • Layer-by-layer (LbL) assembly is a self-assembly technique for creating multilayer films via complementary interactions.
  • Multilayer films significantly impact cellular and tissue engineering applications.
  • Cellular engineering aims to understand and control cell behavior for biomedical therapies.

Purpose of the Study:

  • To review the applications of LbL assembly in cellular and tissue engineering.
  • To highlight the versatility of LbL films in biomedical applications.
  • To discuss the design principles and therapeutic potential of LbL-based films.

Main Methods:

  • LbL assembly technique utilizing complementary interactions.
  • Fabrication of multilayer films with tunable properties.
  • Incorporation of diverse species (proteins, small molecules) into films.

Main Results:

  • LbL films demonstrate significant impact in cellular and tissue engineering.
  • Tunable chemical and mechanical properties allow versatile applications.
  • Films can be designed for therapeutic release or direct biological interaction.

Conclusions:

  • LbL assembly is a powerful tool for developing advanced biomaterials.
  • LbL films offer tailored solutions for regenerative medicine and cell-based therapies.
  • The adaptability of LbL films supports diverse biomedical engineering challenges.