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Open Angle Glaucoma: Treatment

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...

Angle Closure Glaucoma: Treatment

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...

Glaucoma: Overview

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...

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Related Experiment Video

Updated: May 1, 2026

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

Visual field improvement in the collaborative initial glaucoma treatment study.

David C Musch¹, Brenda W Gillespie², Paul F Palmberg³

¹Department of Ophthalmology and Visual Sciences, Medical School, University of Michigan, Ann Arbor, Michigan; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan.

American Journal of Ophthalmology

|April 15, 2014

Summary

This summary is machine-generated.

Visual field improvement and loss were similar in glaucoma patients for 5 years. Better intraocular pressure control predicted visual field improvement, suggesting real gains in glaucoma treatment.

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Area of Science:

Ophthalmology
Clinical Research

Background:

Open-angle glaucoma (OAG) is a leading cause of irreversible blindness.
Effective management strategies aim to preserve visual function and prevent further vision loss.

Purpose of the Study:

To critically evaluate visual field (VF) improvement in the Collaborative Initial Glaucoma Treatment Study (CIGTS).
To identify factors associated with visual field improvement in OAG patients.

Main Methods:

Analysis of a prospective, randomized clinical trial comparing trabeculectomy and topical medications for OAG.
Evaluation of visual field tests (mean deviation) in 607 newly diagnosed OAG subjects over time.
Statistical modeling to determine factors predicting VF improvement.

Main Results:

Substantial VF improvement and loss were comparable through 5 years; VF loss increased thereafter.
Better intraocular pressure (IOP) control (lower mean, minimum, and sustained IOP) significantly predicted VF improvement.
Female sex and specific baseline characteristics were also associated with VF improvement.

Conclusions:

Visual field improvement in CIGTS was comparable to loss for up to 5 years, with loss becoming more common later.
Predictive factors, particularly improved IOP control, support the reality of observed VF improvements.
Findings emphasize the importance of IOP management in preserving vision in glaucoma patients.