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Updated: May 1, 2026
Primer-Free Aptamer Selection Using A Random DNA Library
Published on: July 26, 2010
Amino group binding peptide aptamers with double disulphide-bridged loops selected by in vitro selection using cDNA
Yuki Mochizuki1, Koichi Nishigaki, Naoto Nemoto
1Graduate School of Science and Engineering, Saitama University, 255 Shimo-Okubo, Sakura-ku, Saitama 338-8570, Japan. nemoto@fms.saitama-u.ac.jp.
Abstract:
Peptide aptamers that specifically bind to the amino group on a solid-phase were screened by in vitro selection using the cDNA display method. The identified peptides have a unique structure containing two cyclic loops with disulphide bonds and a linkage region, which were indispensable for molecular recognition.
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