Related Experiment Video

Updated: May 1, 2026

A Rat Model of Pressure Overload Induced Moderate Remodeling and Systolic Dysfunction as Opposed to Overt Systolic Heart Failure
07:13

A Rat Model of Pressure Overload Induced Moderate Remodeling and Systolic Dysfunction as Opposed to Overt Systolic Heart Failure

Published on: April 30, 2020

6.1K

Patterns of left ventricular remodeling among patients with essential and secondary hypertension

Dan Radulescu, Laurentiu Stoicescu, Elena Buzdugan

    Revista Medica De Chile
    |April 15, 2014
    PubMed

    Insights

    Left ventricular hypertrophy (LVH) is more prevalent in secondary hypertension. Remodeling patterns depend on gender, age, hypertension type, blood pressure, and duration.

    Area of Science:

    • Cardiology
    • Hypertension Research
    • Echocardiography

    Background:

    • High blood pressure is a known cause of left ventricular hypertrophy (LVH).
    • LVH is a significant negative prognostic factor in hypertensive individuals.

    Purpose of the Study:

    • To evaluate left ventricular geometric remodeling patterns.
    • To compare patterns in essential hypertension versus secondary hypertension due to renal disease.

    Main Methods:

    • Echocardiographic analysis of 350 hypertensive patients (250 essential, 100 secondary).
    • Measurement of interventricular septum and posterior wall thickness.
    • Calculation of left ventricular mass using the Devereaux formula.

    Main Results:

    • Eccentric LVH common in females with essential hypertension; concentric LVH (cLVH) in males.
    • cLVH was the predominant pattern in secondary hypertension for both genders.
    • Higher LVH prevalence, left ventricular mass index, and wall thickness in secondary hypertension.
    • Remodeling influenced by age, blood pressure, and hypertension duration.

    Conclusions:

    • Secondary hypertension is associated with a higher prevalence of LVH.
    • Ventricular remodeling is multifactorial, influenced by patient demographics and hypertension characteristics.
    Abstract

    More Related Videos

    A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats07:31

    A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats

    Published on: December 2, 2016

    9.8K
    Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction09:20

    Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction

    Published on: February 13, 2021

    6.1K

    Related Concept Videos

    Heart Failure II: Pathophysiology01:29

    Heart Failure II: Pathophysiology

    Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
    1.9K
    Mitral Regurgitation I: Introduction01:20

    Mitral Regurgitation I: Introduction

    Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
    1.3K
    Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

    Cardiomyopathy III: Hypertrophic Cardiomyopathy

    Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
    805
    Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

    Hypertension III: Clinical Manifestations and Diagnostic Studies

    Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
    886
    Hypertension II: Pathophysiology01:29

    Hypertension II: Pathophysiology

    Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
    1.8K
    Pathophysiology of Heart Failure01:17

    Pathophysiology of Heart Failure

    Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
    4.8K