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Phenotypically heterogeneous populations in spatially heterogeneous environments.

Pintu Patra1, Stefan Klumpp1

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|April 16, 2014
PubMed
Summary

Phenotypically heterogeneous bacterial populations, with both normal and persister cells, spread faster in antibiotic environments. This phenotypic diversity provides a significant fitness advantage for population expansion in challenging, nonuniform conditions.

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Area of Science:

  • Microbiology and Evolutionary Biology
  • Population Dynamics and Spatial Expansion

Background:

  • Phenotypic heterogeneity within a population can enhance survival and expansion in changing environments.
  • Bacterial populations often comprise subpopulations with differing growth rates and stress tolerance, such as normal and persister cells.

Purpose of the Study:

  • To investigate the spatial expansion dynamics of a phenotypically heterogeneous bacterial population crossing an antibiotic gradient.
  • To determine if phenotypic diversity confers a fitness advantage in nonuniform environments.

Main Methods:

  • Analysis of bacterial population crossing dynamics using mean first arrival times.
  • Characterization of population behavior through an analytical approximation.
  • Modeling of a population composed of fast-growing normal cells and slow-growing, antibiotic-tolerant persister cells.

Main Results:

  • The crossing dynamics exhibit complex behavior with three distinct scaling regimes.
  • An analytical approximation successfully explains the observed scaling behaviors.
  • Phenotypically heterogeneous populations demonstrate a fitness advantage over homogeneous ones.

Conclusions:

  • Phenotypic heterogeneity, specifically the coexistence of normal and persister cells, facilitates more rapid spatial expansion in nonuniform environments.
  • The study highlights the ecological and evolutionary benefits of phenotypic diversity for population spread and survival.