A novel method for tinidazole detection using Mn-modified CdSe/CdS quantum dots as a luminescent probe

Area of Science:

• Analytical Chemistry
• Materials Science
• Nanotechnology

Background:

• Tinidazole is an important antimicrobial agent.
• Accurate and sensitive detection methods are crucial for pharmaceutical quality control.

Purpose of the Study:

• To develop a novel fluorescence quenching-based method for tinidazole determination.
• To utilize citrate-capped Mn-modified CdSe/CdS quantum dots as a sensing platform.

Main Methods:

• Synthesis of citrate-capped Mn-modified CdSe/CdS quantum dots.
• Investigation of fluorescence quenching of quantum dots by tinidazole in aqueous solution.
• Optimization of reaction conditions for tinidazole detection.

Main Results:

• A good linear relationship was observed between fluorescence quenching and tinidazole concentration (4-400 µM, R²=0.9998).
• The method achieved a low limit of detection of 0.4 µM.
• Successful application of the method for tinidazole determination in tablets and injections.

Conclusions:

• The developed method offers a simple, fast, and cost-effective approach for tinidazole quantification.
• Mn-modified CdSe/CdS quantum dots show great potential as fluorescent probes for drug analysis.