Related Experiment Video
Updated: May 1, 2026

Rewiring Neuronal Circuits: A New Method for Fast Neurite Extension and Functional Neuronal Connection
Published on: June 13, 2017
A chemical approach to "rewire" neural progenitor cells
Min-Zu Wu1, Mo Li1, Guang-Hui Liu2
1Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 N. Torrey Pines Rd., La Jolla, CA 92037, USA.
Abstract:
Generation of neural progenitor cells (NPCs) from pluripotent stem cells including ESCs and iPSCs and derivation of NPCs from somatic tissues have been considered promising approaches that could be used therapeutically to restore function in patients suffering neurodegenerative diseases. A new study published in Cell Research shows, for the first time, the generation of NPCs from somatic cells by small molecule compounds under hypoxia without exogenous transcription factors.

