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Genome-scale metabolic models of yeast, methods for their reconstruction, and other applications

Sergio Bordel1

  • 1Department of Chemical and Biological Engineering, Chalmers University of Technology, Kemivägen 10, Gothenburg, 412 96, Sweden, velasco@chalmers.se.

Methods in Molecular Biology (Clifton, N.J.)
|April 19, 2014
PubMed

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Strain improvement is a foundational strategy in industrial microbiology aimed at maximizing microbial productivity, particularly because natural isolates typically yield commercially valuable products in very low concentrations. Although optimizing the culture medium and environmental conditions can improve yields, these adjustments are inherently limited by the organism’s genetic potential. As a result, the focus shifts toward genetic modifications to enhance biosynthetic capacity. The...
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