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Updated: May 1, 2026
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Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
Published on: June 15, 2019
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Sepsis: current dogma and new perspectives.
Clifford S Deutschman1, Kevin J Tracey2
1Department of Anesthesiology and Critical Care and Surgery and Sepsis Research Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Immunity
|April 22, 2014
Summary
Sepsis causes widespread organ failure and death, but current immunology falls short. New research explores immunometabolic and neurophysiological pathways to understand and treat this critical condition.
Area of Science:
- Immunology
- Pathophysiology
- Critical Care Medicine
Background:
- Sepsis is a major global cause of death and illness.
- Existing immunological models fail to explain sepsis-induced organ failure.
- Understanding cellular dysfunction is crucial for effective sepsis treatment.
Purpose of the Study:
- To review current understanding of sepsis pathophysiology.
- To propose novel immunometabolic and neurophysiological mechanisms.
- To identify new therapeutic targets for sepsis.
Main Methods:
- Review of current scientific literature on sepsis.
- Analysis of immunological, metabolic, and neurophysiological pathways.
- Synthesis of evidence to support new hypotheses.
Main Results:
- Current dogma inadequately explains sepsis-induced cellular dysfunction.
- Altered cellular bioenergetics are implicated in organ failure.
- Epithelial and endothelial barrier dysfunction contribute to sepsis severity.
Conclusions:
- Novel immunometabolic and neurophysiological mechanisms are critical for understanding sepsis.
- Targeting these pathways may offer new therapeutic strategies.
- Further research into cellular bioenergetics and barrier function is warranted.
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