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Related Concept Videos

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Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
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The trp operon in Escherichia coli exemplifies a repressible operon. It regulates the synthesis of tryptophan through repressor-mediated transcriptional control and attenuation. This dual regulatory mechanism ensures tryptophan biosynthesis occurs only when needed, conserving cellular resources.Structure of the trp OperonThe trp operon consists of five structural genes (trpE, trpD, trpC, trpB, and trpA) that encode enzymes for tryptophan biosynthesis. These genes are transcribed as a single...
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Some GPCRs transmit signals through adenylyl cyclase (AC), a transmembrane enzyme. AC helps synthesize second messenger cyclic adenosine monophosphate (cAMP). AC catalyzes cyclization reaction and converts ATP to cAMP by releasing a pyrophosphate. The pyrophosphate is further hydrolyzed to phosphate by the enzyme pyrophosphatase, which drives cAMP synthesis to completion. However, cAMP is rapidly degraded to 5′ AMP by the enzymes phosphodiesterase (PDE), preventing overstimulation of...
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G Protein-coupled Receptors01:15

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G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
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G protein-coupled receptor (GPCR) signaling plays a crucial role in cell functioning. GPCR desensitization is an equally essential process. It allows cells to respond to changing environments and regain sensitivity to new stimuli while preventing unnecessary stimulation when no longer needed. Prolonged exposure to stimuli leads to GPCR desensitization. It involves blocking the receptors from binding and activating additional G proteins. This inhibits activation of downstream effectors, thereby...
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G Protein–Coupled Receptors (GPCRs) are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to various stimuli. GPCRs regulate critical physiological pathways and are excellent drug targets for treating diseases such as diabetes, cancer, obesity, depression, or Alzheimer's. Nearly 35% of approved drugs implement their therapeutic effects by selectively interacting with specific GPCRs.
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Related Experiment Video

Updated: Apr 30, 2026

Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy
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Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy

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TRPC1.

Vasyl Nesin1, Leonidas Tsiokas

  • 1Department of Cell Biology, University of Oklahoma Health Sciences Center, 975 NE 10th Street, Oklahoma City, OK, 73104, USA.

Handbook of Experimental Pharmacology
|April 24, 2014
PubMed
Summary
This summary is machine-generated.

The TRPC1 ion channel is crucial for cell signaling and function, impacting basic cellular processes and various organ systems. Ablating the TRPC1 gene in mice reveals its essential role in development and disease, highlighting its therapeutic potential.

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Area of Science:

  • Molecular Biology
  • Cell Biology
  • Physiology

Background:

  • TRPC1 is the first cloned mammalian TRP channel, encoded by the TRPC1 gene on chromosome 3.
  • It forms a cation-nonselective channel involved in Ca(2+) signaling pathways.
  • TRPC1 is ubiquitously expressed and localized in various cellular compartments, including the endoplasmic reticulum and plasma membrane.

Purpose of the Study:

  • To elucidate the structure, function, and biological significance of the TRPC1 ion channel.
  • To investigate the physiological roles of TRPC1 in cellular processes and organ systems.
  • To explore the implications of TRPC1 dysfunction in human diseases.

Main Methods:

  • Cloning and characterization of the TRPC1 gene and protein.
  • Localization studies in human and rodent tissues.
  • Functional analysis using genetically engineered mice with TRPC1 gene ablation.
  • Correlation of TRPC1 function with various disease models.

Main Results:

  • TRPC1 protein structure consists of six transmembrane segments, with pore-forming regions in the extracellular loop.
  • TRPC1 mediates Ca(2+) entry, influencing cell proliferation, survival, differentiation, secretion, and migration.
  • TRPC1 knockout mice exhibit defects in cardiovascular, nervous, skeletal, muscular, and immune systems.
  • TRPC1 is implicated in diabetic nephropathy, Parkinson's, Huntington's, muscular dystrophy, cancer, seizures, and Darier-White disease.

Conclusions:

  • TRPC1 is a vital ion channel with widespread physiological roles.
  • TRPC1 dysfunction contributes to the pathogenesis of numerous diseases.
  • Targeting TRPC1 may offer therapeutic strategies for various human conditions.