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Related Experiment Video

Updated: Apr 30, 2026

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4

Published on: December 31, 2013

TRPV3.

Pu Yang¹, Michael X Zhu

¹Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.

Handbook of Experimental Pharmacology

|April 24, 2014

Summary

This summary is machine-generated.

Transient receptor potential vanilloid-3 (TRPV3) channels in skin keratinocytes are activated by warm temperatures and regulate skin functions. Genetic mutations reveal TRPV3

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Area of Science:

Physiology
Molecular Biology
Dermatology

Background:

Transient receptor potential vanilloid-3 (TRPV3) is a calcium-permeable cation channel.
TRPV3 is expressed in skin keratinocytes and oral/nasal epithelia.
It is activated by warm and hot temperatures.

Purpose of the Study:

To elucidate the physiological functions of TRPV3.
To understand the regulatory mechanisms of TRPV3.
To investigate the role of TRPV3 in skin health and disease.

Main Methods:

Utilized genetic mouse models.
Investigated TRPV3 activation by various stimuli.
Analyzed regulatory mechanisms involving ions and lipids.
Examined gain-of-function mutations in rodents and humans.

Main Results:

TRPV3 activation in keratinocytes releases substances regulating skin barrier, hair growth, wound healing, temperature sensing, itch, and pain.
Identified farnesyl pyrophosphate as a natural TRPV3 ligand.
Revealed regulation by extracellular/intracellular ions (Ca2+, Mg2+), protons, ATP, and lipids.
Demonstrated the critical role of TRPV3 in skin health and disease through genetic mutations.

Conclusions:

TRPV3 plays a significant role in skin physiology and homeostasis.
Dysregulation of TRPV3 is implicated in various skin conditions.
Further research into TRPV3 modulators could offer therapeutic potential for skin diseases.