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Thermosensation

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Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...

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Related Experiment Video

Updated: Apr 30, 2026

A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice

A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice

Published on: March 17, 2015

TRPM6.

Vladimir Chubanov¹, Thomas Gudermann

¹Walther-Straub-Institute for Pharmacology and Toxicology, Ludwig-Maximilians University Munich, Goethestrasse 33, Munich, 80336, Germany, vladimir.chubanov@lrz.uni-muenchen.de.

Handbook of Experimental Pharmacology

|April 24, 2014

Summary

This summary is machine-generated.

The TRPM6 channel kinase is crucial for magnesium homeostasis in adults. Loss of function causes hypomagnesemia with secondary hypocalcemia, while its absence leads to developmental defects and prenatal death.

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Last Updated: Apr 30, 2026

A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice

A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice

Published on: March 17, 2015

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4

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Published on: December 31, 2013

Purification and Reconstitution of TRPV1 for Spectroscopic Analysis

Purification and Reconstitution of TRPV1 for Spectroscopic Analysis

Published on: July 3, 2018

Area of Science:

Molecular biology
Human physiology
Developmental biology

Background:

TRPM6 is a bifunctional protein with a cation channel and a kinase domain.
It is expressed in intestinal and renal epithelial cells.
TRPM6 is essential for maintaining systemic magnesium (Mg2+) homeostasis.

Purpose of the Study:

To discuss the functions of TRPM6 in prenatal and adult organisms.
To highlight the role of TRPM6 mutations in human diseases.
To explore the implications of TRPM6 in development and Mg2+ balance.

Main Methods:

Analysis of human genetic data for TRPM6 mutations.
Phenotypic characterization of Trpm6 null mouse models.
Review of existing literature on TRPM6 function.

Main Results:

Loss-of-function mutations in human TRPM6 cause hypomagnesemia with secondary hypocalcemia (HSH).
Trpm6 null mice exhibit delayed prenatal development, neural tube defects, and prenatal lethality.
TRPM6 plays a critical role in both prenatal development and adult Mg2+ regulation.

Conclusions:

TRPM6 is vital for prenatal development and preventing embryonic lethality.
The TRPM6 channel kinase is essential for maintaining systemic Mg2+ homeostasis in adults.
Dysregulation of TRPM6 function has severe consequences for both development and mineral balance.