Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Thermosensation

Thermosensation

Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...

Repressible Operon: trp Operon

Repressible Operon: trp Operon

The trp operon in Escherichia coli exemplifies a repressible operon. It regulates the synthesis of tryptophan through repressor-mediated transcriptional control and attenuation. This dual regulatory mechanism ensures tryptophan biosynthesis occurs only when needed, conserving cellular resources.Structure of the trp OperonThe trp operon consists of five structural genes (trpE, trpD, trpC, trpB, and trpA) that encode enzymes for tryptophan biosynthesis. These genes are transcribed as a single...

G-protein Coupled Receptors

G-protein Coupled Receptors

G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.

LTR Retrotransposons

LTR Retrotransposons

LTR retrotransposons are class I transposable elements with long terminal repeats flanking an internal coding region. These elements are less abundant in mammals compared to other class I transposable elements. About 8 percent of human genomic DNA comprises LTR retrotransposons. Some of the common examples of LTR retrotransposons are Ty elements in yeast and Copia elements in Drosophila.
The internal coding region of LTR retrotransposons and their mechanism of transposition closely resembles a...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The TRPM7 inhibitor carvacrol suppresses angiogenesis and vasculogenic mimicry in triple-negative breast cancer.

International journal of biological sciences·2026

Same author

Pharmacophore Directed Retrosynthesis Applied to Waixenicin A: Synthesis and Bioactivity of Derivatives Bearing a Minimal Proposed Pharmacophore.

Organic letters·2026

Same author

Open-channel block of human TRPV6 by polyamine spermine.

Nature communications·2026

Same author

TRPM7 kinase inhibitor TG100-115 provides neuroprotection against neonatal hypoxic-ischemic brain injury.

Acta pharmacologica Sinica·2026

Same author

Dapagliflozin-Associated Resolution of Acute Carboplatin-Induced Hypomagnesemia-Exploration of TRPM6/7 Channel Activity.

Kidney international reports·2025

Same author

The locking mechanism of human TRPV6 inhibition by intracellular magnesium.

Nature communications·2025

Same journal

Endothelial Cell Phenotypic Plasticity in Atherosclerosis.

Handbook of experimental pharmacology·2026

Same journal

Endothelial Dysfunction and Neurovascular Alterations in Autism Spectrum Disorder.

Handbook of experimental pharmacology·2026

Same journal

Molecular Mechanisms of Endothelial Shear Stress Mechanotransduction in Health and Disease.

Handbook of experimental pharmacology·2026

Same journal

Microvasculature of the Pancreatic Islets of Langerhans in Health and Diabetes.

Handbook of experimental pharmacology·2026

Same journal

Mechanisms of Actions of Physiological, Pharmacological, and Toxicological Dietary Bioactive Inorganic Boron.

Handbook of experimental pharmacology·2026

Same journal

BNCT Plus Luminescence: New Paradigm for Boron-Containing Drug Design.

Handbook of experimental pharmacology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Apr 30, 2026

A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice

A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice

Published on: March 17, 2015

TRPM7.

Andrea Fleig¹, Vladimir Chubanov

¹Center for Biomedical Research at The Queen's Medical Center, Honolulu, HI, USA, afleig@queens.org.

Handbook of Experimental Pharmacology

|April 24, 2014

Summary

This summary is machine-generated.

Transient Receptor Potential Melastatin 7 (TRPM7) is a vital channel kinase found in all mammalian tissues. Its role in magnesium homeostasis impacts development, ischemia, cardiovascular disease, and cancer.

More Related Videos

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4

Published on: December 31, 2013

Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy

Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy

Published on: January 7, 2019

Related Experiment Videos

Last Updated: Apr 30, 2026

A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice

A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice

Published on: March 17, 2015

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4

Published on: December 31, 2013

Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy

Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy

Published on: January 7, 2019

Area of Science:

Biochemistry
Molecular Biology
Physiology

Background:

TRPM6 and TRPM7 are fusion proteins possessing both ion transport and kinase domains.
TRPM7 exhibits ubiquitous expression across all investigated mammalian tissues.
The unique structure and function of TRPM7 suggest its involvement in diverse physiological processes.

Purpose of the Study:

To elucidate the multifaceted roles of TRPM7 in physiological and pathological conditions.
To highlight the significance of TRPM7 in magnesium homeostasis.
To underscore TRPM7's involvement in key health areas including development, ischemia, cardiovascular disease, and cancer.

Main Methods:

Investigated the expression profile of TRPM7 in mammalian tissues.
Analyzed the biophysical characteristics of TRPM7 related to divalent ion transport.
Correlated TRPM7 function with various (patho)physiological processes.

Main Results:

TRPM7 is ubiquitously expressed in mammalian tissues.
TRPM7's dual function enables significant divalent ion transport.
TRPM7 plays a critical role in cellular and systemic magnesium homeostasis.

Conclusions:

TRPM7 is a crucial protein involved in numerous physiological and pathological processes.
TRPM7's function in magnesium regulation is essential for embryonic development.
TRPM7 is implicated in the pathophysiology of global ischemia, cardiovascular disease, and cancer.