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Bioengineering approaches to guide stem cell-based organogenesis.

Nikolche Gjorevski¹, Adrian Ranga, Matthias P Lutolf

¹Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, Lausanne CH-1015, Switzerland.

Development (Cambridge, England)

|April 24, 2014

Summary

This summary is machine-generated.

Bioengineering advances organogenesis research by enabling precise control over stem cell microenvironments. This approach bridges the gap between in vitro tissue models and in vivo development, aiding drug discovery and regenerative medicine.

Keywords:

3D culture Bioengineering Biomaterials Organoid Stem cell

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Area of Science:

Developmental biology
Bioengineering
Stem cell biology

Background:

Organogenesis involves complex spatio-temporal signaling, challenging in vivo studies, especially in mammals.
Stem cell-derived tissues offer organotypic models but differ from in vivo counterparts due to microenvironment and mesenchymal influences.

Purpose of the Study:

To explore how bioengineering can enhance stem cell-driven tissue formation ex vivo.
To bridge the gap between in vitro tissue assembly and in vivo organogenesis.
To identify new models for drug discovery and clinical tissue regeneration.

Main Methods:

Utilizing advances in biomaterials and microtechnology for spatiotemporal control of cellular microenvironments.
Developing organ-specific synthetic culture models.
Examining stem cell-derived organoids as examples of bioengineered tissue formation.

Main Results:

Bioengineering provides high spatiotemporal control over the cellular microenvironment.
It enables interrogation of individual microenvironmental components and identification of synthetic culture models.
Stem cell-derived organoids demonstrate the potential of bioengineering for ex vivo tissue formation.

Conclusions:

Bioengineering approaches are crucial for understanding organogenesis and improving stem cell-based tissue models.
These strategies offer mechanistic insights into development and pave the way for clinical applications in drug discovery and regenerative medicine.
Overcoming current challenges in bioengineering will further advance ex vivo tissue formation and its clinical translation.