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Closed-loop artificial pancreas systems: physiological input to enhance next-generation devices.
Yogish C Kudva1, Rickey E Carter, Claudio Cobelli
1Corresponding author: Ananda Basu, basu.ananda@mayo.edu.
Diabetes Care
|April 24, 2014
Summary
This review explores artificial pancreas systems for type 1 diabetes, covering preclinical insulin-glucose-glucagon physiology and clinical technology evaluations to advance outpatient trials and widespread use.
Area of Science:
- Biomedical Engineering
- Endocrinology
- Diabetes Technology
Background:
- Type 1 diabetes management requires sophisticated glucose control.
- Artificial pancreas systems offer a promising avenue for improved glycemic regulation.
- Understanding both physiological underpinnings and technological advancements is crucial.
Purpose of the Study:
- To present a comprehensive overview of closed-loop artificial pancreas systems.
- To bridge the gap between preclinical research and clinical application.
- To facilitate the development and adoption of artificial pancreas technology.
Main Methods:
- Review of preclinical research focusing on insulin-glucose-glucagon dynamics in type 1 diabetes.
- Analysis of current closed-loop system technologies and clinical trial data.
- Discussion of challenges and future directions for artificial pancreas development.
Main Results:
- Preclinical insights into physiological mimicry are vital for algorithm refinement.
- Clinical evaluation of existing technologies highlights progress toward outpatient systems.
- The 'Bench to Clinic' narrative integrates fundamental science with practical application.
Conclusions:
- Advancing artificial pancreas technology requires a dual focus on physiological understanding and clinical evaluation.
- Continued research and development are essential for widespread adoption and regulatory approval.
- These systems hold significant potential to improve the quality of life for individuals with type 1 diabetes.
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