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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

2.5K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Cancer Vaccines01:30

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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
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Treatment Resistant Cancers02:56

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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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Updated: Apr 30, 2026

Flow Cytometry-Based Isolation and Therapeutic Evaluation of Tumor-Infiltrating Lymphocytes in a Mouse Model of Pancreatic Cancer
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Immunotherapy in sarcoma: a new frontier.

Breelyn A Wilky1, John M Goldberg2

  • 1Department of Medicine Division of Hematology/Oncology, University of Miami Miller School of Medicine / Sylvester Comprehensive Cancer Center, Miami, FL 33136, USA.

Discovery Medicine
|April 25, 2014
PubMed
Summary
This summary is machine-generated.

Immunotherapy offers new hope for rare soft tissue and bone sarcomas, especially when standard treatments fail. Research into immune system applications, including vaccines and checkpoint inhibitors, presents promising clinical trial options for patients.

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Area of Science:

  • Oncology
  • Immunology

Background:

  • Sarcomas, rare cancers of soft tissue and bone, are often incurable with standard treatments.
  • Advances in immunotherapy for solid tumors are driving interest in its role in sarcoma.

Purpose of the Study:

  • To review current laboratory and clinical research on immunotherapy for sarcoma treatment.
  • To highlight the potential of immunotherapy as a treatment option for sarcoma patients.

Main Methods:

  • Literature review of ongoing laboratory and clinical research.
  • Summary of various immunotherapy approaches being investigated.

Main Results:

  • Multiple immunotherapy strategies are under investigation for sarcoma.
  • These include vaccine therapy, adoptive cell transfer, biochemotherapy, and immune checkpoint inhibitors.

Conclusions:

  • Immunotherapy presents a promising avenue for treating refractory sarcomas.
  • Clinical trials offer valuable treatment options, alone or with traditional therapies.