[J-GRID and SATREPS programs in Thailand]

Area of Science:

• Virology
• Immunology
• Infectious Diseases

Context:

• Established research centers like RCC-ERI and MOCID foster Thailand-Japan collaboration on emerging and re-emerging infections.
• International joint research programs, such as SATREPS, support global health initiatives by addressing critical health issues.

Purpose:

• To present an overview of research activities at the Thailand-Japan Research Collaboration Center on Emerging and Re-emerging Infections (RCC-ERI) and Mahidol-Osaka Center for Infectious Diseases (MOCID).
• To detail phenotypic studies on HIV-1 envelope glycoproteins from Thai strains.
• To describe the generation of human monoclonal antibodies against dengue and influenza viruses for potential therapeutic use.

Summary:

• Epidemiological and basic studies on human pathogenic viruses are conducted at RCC-ERI and MOCID.
• Phenotypic studies focused on HIV-1 envelope glycoproteins from Thai strains were performed at RCC-ERI.
• A collaborative project aimed to generate human monoclonal antibodies against dengue and influenza viruses, with potential clinical applications as therapeutic antibodies.

Impact:

• The research contributes to understanding viral pathogenesis and developing novel therapeutic strategies against infectious diseases.
• Successful generation of neutralizing human monoclonal antibodies could lead to new treatments for viral infections.
• Strengthened international research collaboration between Thailand and Japan in the field of infectious disease control.