Related Experiment Video
Updated: Apr 30, 2026

A Mouse Distraction Osteogenesis Model
Published on: November 14, 2018
The distraction osteogenesis in midfacial hypoplasia
Alessandra Lucchese1, Enrico F Gherlone, Paolo Asperio
1From the *Department of Orthodontics; †Department of Dentistry, Dental School, Vita Salute University, San Raffaele Hospital, Milan; ‡Department of Maxillo Facial Surgery, Cardinal Massaia Hospital, Asti; and §Department of Clinico Surgical, Diagnostic and Pediatric Sciences, School of Dentistry, University of Pavia, Pavia, Italy.
Distraction osteogenesis (DO) effectively treats severe midfacial retrusion in cleft patients. This method using a rigid external distraction (RED) device improved facial balance, dental alignment, and patient self-esteem.
Area of Science:
- Craniofacial surgery
- Orthodontics
- Regenerative medicine
Background:
- Severe midfacial retrusion in cleft patients causes masticatory and psychological issues.
- Distraction osteogenesis (DO) is a technique for generating new bone via tensile stress.
- Rigid external distraction (RED) devices offer a method for controlled bone movement.
Purpose of the Study:
- To present the clinical outcomes of treating a cleft patient with severe maxillary deficiency using a RED device.
- To improve facial profile, maxillary incisal display, overjet/overbite, and dental alignment.
- To evaluate the stability and impact on velopharyngeal competence.
Main Methods:
- A Le Fort I osteotomy was performed on a cleft patient with severe maxillary deficiency.
- A rigid external distraction (RED) device was applied, with traction directed to the maxilla via an intraoral splint.
- The RED device's halo was secured to the cranium with scalp screws.
Main Results:
- A well-balanced facial profile and good dental alignment were achieved.
- The patient experienced significant improvement in self-esteem.
- Maxillary advancements via distraction showed stability with minimal velopharyngeal impact.
Conclusions:
- Distraction osteogenesis with a RED device is effective for correcting severe maxillary deficiency in cleft patients.
- This treatment approach leads to improved aesthetics, function, and psychological well-being.
- Maxillary advancement using distraction osteogenesis offers a stable alternative to traditional orthognathic surgery.
More Related Videos
09:26An Efficient and Reproducible Protocol for Distraction Osteogenesis in a Rat Model Leading to a Functional Regenerated Femur
Published on: October 23, 2017
07:35Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects
Published on: April 11, 2012