Endoscopic submucosal dissection using a new scissors-type electrosurgical knife: a first-in-human feasibility study.

Area of Science:

• Gastroenterology
• Surgical Technology
• Endoscopy

Background:

• Endoscopic submucosal dissection (ESD) presents challenges and higher complication rates compared to conventional endoscopic resection.
• A novel scissors-type electrosurgical knife was developed to enhance ESD's durability and usability.

Purpose of the Study:

• To evaluate the feasibility of a new scissors-type electrosurgical knife for endoscopic submucosal dissection (ESD).
• To assess the safety and efficacy of the novel device in resecting early esophageal and gastric cancers.

Main Methods:

• Initial ex vivo and live animal model experiments were conducted.
• A human feasibility study involved patients with early esophageal or gastric cancer undergoing ESD.
• The primary endpoint was the incidence of serious adverse events (SAE) related to ESD.

Main Results:

• The novel scissors-type knife showed no mechanical errors or significant tissue damage in preclinical models.
• In the human study, four patients underwent successful ESD procedures with a mean duration of 31 minutes.
• Complete tumor resection was achieved in all patients without any serious adverse events; the device functioned smoothly.

Conclusions:

• Endoscopic submucosal dissection (ESD) using the new scissors-type electrosurgical knife is a feasible and safe option for early esophageal and gastric cancers.