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Updated: Apr 30, 2026
Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos
Published on: December 13, 2018
Transplanted tumor growth inhibition by functionalized short single-walled carbon nanotubules
O I Kit1, E Yu Zlatnik, L V Peredreyeva
1Rostov Research Oncological Institute, Ministry of Health of the Russian Federation, Rostov-on-Don, Russia.
Abstract:
The effects of short single-walled carbon nanotubules functionalized by COOH- and NH2- containing groups (NT-COOH and NT-NH2), on the dynamics of transplanted Pliss lymphosarcoma growth were studied after tumor cell preincubation with nanotubules and after injection of nanotubules into the developing tumor. Tumor growth was inhibited and the lifespan of rats with tumors was prolonged by 1.7 times after transplantation of tumor preincubated with NT-NH2, while NT-COOH caused no effect of this kind. Intratumor injection of NT-NH2 inhibited tumor growth over 3 weeks and prolonged animal lifespan.
Insights
Short single-walled carbon nanotubes functionalized with amine groups (NT-NH2) significantly inhibited tumor growth and extended rat lifespan. Carboxylic acid-functionalized nanotubes (NT-COOH) showed no such effect, highlighting the importance of functionalization.
Area of Science:
- Biomedical Engineering
- Materials Science
- Oncology
Background:
- Cancer research explores novel therapeutic agents.
- Carbon nanotubes offer unique properties for biomedical applications.
- Functionalization of nanomaterials is key to tailoring their biological effects.
Purpose of the Study:
- To investigate the impact of functionalized carbon nanotubes on lymphosarcoma growth dynamics.
- To compare the efficacy of amine-functionalized (NT-NH2) and carboxylic acid-functionalized (NT-COOH) nanotubes.
- To evaluate therapeutic effects via preincubation and direct intratumoral injection.
Main Methods:
- Short single-walled carbon nanotubes functionalized with COOH- and NH2- groups were synthesized.
- Pliss lymphosarcoma cells were preincubated with nanotubes.
- Nanotubes were injected directly into developing tumors in rats.
- Tumor growth dynamics and animal survival rates were monitored.
Main Results:
- Preincubation with NT-NH2 significantly inhibited tumor growth and extended rat lifespan by 1.7 times.
- NT-COOH showed no significant inhibitory effect on tumor growth or lifespan.
- Intratumoral injection of NT-NH2 also demonstrated tumor growth inhibition over 3 weeks and prolonged survival.
Conclusions:
- Amine functionalization of short single-walled carbon nanotubes imparts potent anti-tumor properties.
- NT-NH2 represents a promising candidate for further investigation in cancer therapy.
- The specific functional groups on carbon nanotubes critically determine their biological efficacy in cancer models.
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