[Cutaneous B-cell lymphoma]

Area of Science:

• Dermatology
• Oncology
• Hematology

Context:

• Primary cutaneous B-cell lymphomas (PCBCL) are distinct neoplasms presenting solely in the skin.
• Accurate diagnosis is crucial to differentiate from systemic lymphomas with secondary skin involvement.

Purpose:

• To summarize the clinical and histopathological characteristics of major PCBCL subtypes.
• To outline staging procedures for differentiating primary cutaneous from secondary involvement.
• To review current treatment modalities for PCBCL.

Summary:

• Focuses on three main PCBCL types: marginal zone lymphoma, follicle center lymphoma, and diffuse large B-cell lymphoma (leg type).
• Emphasizes staging to exclude extracutaneous disease.
• Discusses localized treatments (radiotherapy, surgery) for indolent forms and chemotherapy for aggressive leg-type PCBCL.

Impact:

• Provides a comprehensive overview for clinicians managing PCBCL.
• Aids in accurate diagnosis and staging, crucial for appropriate treatment selection.
• Informs treatment decisions, optimizing outcomes for patients with PCBCL.