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Updated: Aug 10, 2026

Murine Model of Allergen Induced Asthma
Published on: May 14, 2012
Human immune response against timothy grass pollen allergens. I. Shared idiotypes on human and murine
1Oregon Regional Primate Research Center, Beaverton.
Abstract:
Enzyme-linked immunoassays were used to examine the binding specificity of affinity-purified anti-idiotypic antibody [against the idiotypic determinant on timothy grass pollen antigen B (AgB)-specific IgE] with murine AgB-specific IgG and IgE antibodies, and the serum from timothy-sensitive patients. In addition, the proliferative response of peripheral blood lymphocytes from timothy-sensitive patients with either antigen or anti-idiotypic antibody was examined. These studies suggest that the idiotypic determinant expressed on murine AgB-specific IgE is highly conserved on human AgB-specific IgE and T cells of timothy-sensitive patients.
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