Related Experiment Video
Updated: Apr 30, 2026

Synthesis of Monodisperse Cylindrical Nanoparticles via Crystallization-driven Self-assembly of Biodegradable Block Copolymers
Published on: June 20, 2019
End-group-functionalized poly(N,N-diethylacrylamide) via free-radical chain transfer polymerization: Influence of
Sebastian Reinelt1, Daniel Steinke1, Helmut Ritter1
1Heinrich-Heine-University of Düsseldorf, Institute of Organic Chemistry and Macromolecular Chemistry, Department of Preparative Polymer Chemistry, Universitätsstraße 1, 40225 Düsseldorf, Germany.
Abstract:
In this work we report the synthesis of thermo-, oxidation- and cyclodextrin- (CD) responsive end-group-functionalized polymers, based on N,N-diethylacrylamide (DEAAm). In a classical free-radical chain transfer polymerization, using thiol-functionalized 4-alkylphenols, namely 3-(4-(1,1-dimethylethan-1-yl)phenoxy)propane-1-thiol and 3-(4-(2,4,4-trimethylpentan-2-yl)phenoxy)propane-1-thiol, poly(N,N-diethylacrylamide) (PDEAAm) with well-defined hydrophobic end-groups is obtained. These end-group-functionalized polymers show different cloud point values, depending on the degree of polymerization and the presence of randomly methylated β-cyclodextrin (RAMEB-CD). Additionally, the influence of the oxidation of the incorporated thioether linkages on the cloud point is investigated. The resulting hydrophilic sulfoxides show higher cloud point values for the lower critical solution temperature (LCST). A high degree of functionalization is supported by (1)H NMR-, SEC-, FTIR- and MALDI-TOF measurements.
More Related Videos
Related Concept Videos
Radical Chain-Growth Polymerization: Overview
Cationic Chain-Growth Polymerization: Mechanism
Anionic Chain-Growth Polymerization: Overview
Radical Chain-Growth Polymerization: Chain Branching
Radical Chain-Growth Polymerization: Mechanism
Free-Radical Chain Reaction and Polymerization of Alkenes

