[Norfloxacin concentration in human prostatic tissue after 3 days administration]

Area of Science:

• Pharmacology
• Urology
• Drug Metabolism

Context:

• Benign prostatic hypertrophy (BPH) affects a significant portion of the aging male population.
• Understanding antibiotic penetration into prostatic tissue is crucial for treating associated infections.
• Norfloxacin is a fluoroquinolone antibiotic commonly used for urinary tract infections.

Purpose:

• To evaluate the penetration of norfloxacin into prostatic tissue in patients with BPH.
• To determine the relationship between drug administration timing and tissue/serum concentrations.
• To provide data relevant to optimizing antibiotic therapy for BPH-related conditions.

Summary:

• Norfloxacin (200 mg TID for 3 days) was administered to 36 BPH patients preoperatively.
• Prostatic tissue and serum samples were collected at two time points: approximately 5.5 hours and 17 hours after the final dose.
• Mean norfloxacin concentrations were higher in both prostatic tissue (0.89 µg/g vs. 0.38 µg/g) and serum (0.49 µg/ml vs. 0.18 µg/ml) at 5.5 hours compared to 17 hours.

Impact:

• Demonstrates significant norfloxacin penetration into the prostate gland.
• Suggests that earlier sampling times yield higher drug concentrations.
• Informs potential dosing strategies for norfloxacin in treating prostatic infections.