Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hypoglycemia01:26

Hypoglycemia

30
Hypoglycemia is a blood glucose level below 70 mg/dL. It commonly occurs in individuals using insulin or insulin-secreting drugs, but may also arise in non-diabetic conditions. People with type 1 diabetes are at the highest risk because they depend on exogenous insulin. People with type 2 diabetes are also at risk, especially when treated with insulin or medications such as sulfonylureas, which increase insulin release regardless of blood glucose levels. It develops when insulin levels exceed...
30
Hypoglycemia and Glucagon01:15

Hypoglycemia and Glucagon

1.3K
Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
1.3K
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

410
In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
410
Hyperglycemia01:29

Hyperglycemia

25
Hyperglycemia is an abnormally high blood glucose level. It is diagnosed by fasting glucose ≥126 mg/dL, 2-hour oral glucose tolerance test (or OGTT) ≥200 mg/dL, random glucose ≥200 mg/dL with symptoms, or HbA1c ≥6.5%. However, HbA1c results may be unreliable in certain conditions, such as anemia or hemoglobinopathies, and the diagnosis should be confirmed unless classic symptoms are present. Postprandial hyperglycemia is typically considered significant when glucose...
25
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

967
Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
967
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

554
Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
554

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: Gad et al. Management of Childhood Obesity. <i>Int. J. Mol. Sci.</i> 2026, <i>27</i>, 3528.

International journal of molecular sciences·2026
Same author

Case Report: Effect of setmelanotide treatment in a young patient with acquired hypothalamic obesity following <i>Escherichia coli</i> sepsis and meningoencephalitis with brain abscess.

Frontiers in endocrinology·2026
Same author

Effect of dual hepatic and portal vein embolization on future liver remnant function and volume prior to major hepatectomy.

Annals of hepato-biliary-pancreatic surgery·2026
Same author

Distal ureterectomy versus radical nephroureterectomy for nonmetastatic distal ureteral urothelial carcinoma: a GRADE-assessed systematic review and meta-analysis of comparative studies.

World journal of surgical oncology·2026
Same author

Zaleya pentandra L. produces anti-arthritic effects by downregulating IL-6, NF-κB, and TNF-α and mitigating oxidative stress.

Inflammopharmacology·2026
Same author

Ethnobotanical survey of medicinal plants traditionally used in Daulat Nagar, Punjab, Pakistan.

Journal of ethnobiology and ethnomedicine·2026
Same journal

Cardiovascular disease and miRNA.

Advances in clinical chemistry·2026
Same journal

RNA biomarkers in antidoping.

Advances in clinical chemistry·2026
Same journal

Biomarkers for assessing magnesium status.

Advances in clinical chemistry·2026
Same journal

Advances in microfluidic extracellular vesicle technology.

Advances in clinical chemistry·2026
Same journal

Chronic low-grade inflammation in vegetarians and vegans: Biomarker evidence and methodological considerations.

Advances in clinical chemistry·2026
Same journal

Biomarkers in heart failure.

Advances in clinical chemistry·2026
See all related articles

Related Experiment Video

Updated: Apr 30, 2026

Improving IV Insulin Administration in a Community Hospital
12:08

Improving IV Insulin Administration in a Community Hospital

Published on: June 11, 2012

19.7K

Pediatric hypoglycemia.

Timothy F Lang, Khalid Hussain

    Advances in Clinical Chemistry
    |May 3, 2014
    PubMed
    Summary
    This summary is machine-generated.

    Pediatric hypoglycemia, or low blood sugar in children, requires careful management to prevent brain damage. Advances in genetics offer better treatments, but predicting long-term outcomes and overcoming testing limitations remain challenges.

    More Related Videos

    Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs
    08:58

    Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs

    Published on: October 31, 2025

    882
    Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice
    11:10

    Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice

    Published on: November 16, 2011

    97.6K

    Related Experiment Videos

    Last Updated: Apr 30, 2026

    Improving IV Insulin Administration in a Community Hospital
    12:08

    Improving IV Insulin Administration in a Community Hospital

    Published on: June 11, 2012

    19.7K
    Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs
    08:58

    Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs

    Published on: October 31, 2025

    882
    Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice
    11:10

    Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice

    Published on: November 16, 2011

    97.6K

    Area of Science:

    • Pediatric Endocrinology
    • Neonatal Medicine
    • Molecular Genetics

    Background:

    • Hypoglycemia in children is a common condition that can lead to brain injury if not managed promptly.
    • Recent molecular genetics discoveries have improved understanding of the biochemical and physiological underpinnings of pediatric hypoglycemia.
    • Predicting long-term outcomes for affected children remains challenging despite advances.

    Purpose of the Study:

    • To provide an overview of pediatric hypoglycemia.
    • To discuss the molecular pathways involved in pediatric hypoglycemia.
    • To highlight recent advances and persistent challenges in the field.

    Main Methods:

    • This is a review article, synthesizing current knowledge.
    • It examines recent advances in molecular genetics related to hypoglycemia.
    • It discusses the transition from fetal to neonatal physiology.

    Main Results:

    • Molecular genetics has enhanced understanding and treatment specificity for pediatric hypoglycemia.
    • Improved understanding of neonatal transition aids in surveillance and management.
    • Persistent analytical limitations in point-of-care glucose testing at low concentrations hinder accurate assessment.

    Conclusions:

    • Early recognition and management of pediatric hypoglycemia are crucial to prevent neurological damage.
    • Genetic insights are improving therapeutic strategies, but outcome prediction requires further research.
    • Addressing limitations in current diagnostic tools is essential for optimal patient care.