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Updated: Apr 30, 2026

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
Published on: July 29, 2014
Opioid syndrome: failed opioid therapy for chronic noncancer pain
Leonard B Kamen1, Kristofer J Feeko2
1MossRehab Outpatient Center, Albert Einstein Healthcare Network, 9880 Bustleton Avenue, Suite 309, Philadelphia, PA 19115, USA; Department of Physical Medicine and Rehabilitation, Temple University Hospital, Philadelphia, PA, USA.
Abstract:
Treatment of chronic noncancer pain (CNCP) with high-dose opioids (HDOs) has burgeoned over the past 2 decades in the United States. Characteristic domains and features of the failed CNCP management patient using long-term HDOs are described herein as the/an opioid syndrome (Schreiber AL, personal communication. 2013). Reversing or even modulating HDO use in patients with CNCP requires a paradigm shift on the part of physician, patient, and the societal "quick fix" medical culture. This review offers measures, agents, and strategies to consider in management of this pervasive, erosive medical and societal challenge.
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