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Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
Published on: September 5, 2017
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Current treatment options for latent tuberculosis infection
Marialuisa Bocchino1, Alessandro Matarese, Alessandro Sanduzzi
1Address correspondence to Dr. Bocchino, Università degli Studi di Napoli Federico II, Divisione di Malattie dell'Apparato Respiratorio, Azienda dei Colli (Ospedale Monaldi), Via L. Bianchi 5, 80131 Naples, Italy.
The Journal of Rheumatology. Supplement
|May 3, 2014
Summary
Treating latent tuberculosis infection (LTBI) requires careful consideration of patient risk and adherence. Alternative treatments to isoniazid offer improved adherence and cost-effectiveness for preventing active tuberculosis (TB).
Area of Science:
- Public Health
- Infectious Diseases
- Pharmacology
Background:
- Latent tuberculosis infection (LTBI) treatment is crucial for global tuberculosis (TB) control.
- Targeted screening and treatment for LTBI are essential for cost-effectiveness and patient adherence, especially in high-risk populations.
- Individuals at increased risk for active TB, including those on tumor necrosis factor-α blockers, require specific LTBI management strategies.
Purpose of the Study:
- To review current LTBI treatment strategies, focusing on patient populations at higher risk of developing active TB.
- To evaluate alternative LTBI therapies in comparison to isoniazid, considering effectiveness, adherence, and cost.
- To discuss recommendations, toxicity, compliance, and economic factors influencing LTBI treatment decisions.
Main Methods:
- Literature review of LTBI treatment strategies, guidelines, and comparative studies.
- Analysis of current recommendations for LTBI therapy, including isoniazid and alternative regimens.
- Discussion of factors impacting patient adherence and cost-effectiveness.
Main Results:
- Isoniazid (INH) has been the standard for LTBI treatment but alternatives offering better adherence and cost savings are available.
- Effective, shorter-duration LTBI treatments with fewer side effects are preferred.
- Patient-provider relationships and tailored strategies can enhance adherence.
Conclusions:
- Optimizing LTBI treatment involves a balanced approach considering patient risk, adherence, and cost-effectiveness.
- Alternative LTBI therapies should be prioritized when they offer improved outcomes and economic benefits.
- Further research and implementation of preferred treatment strategies are needed to enhance global TB control efforts.
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