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Fabrication of solid collagen nanoparticles using electrospray deposition.
Usharani Nagarajan1, Kohsaku Kawakami, Shaoling Zhang
1Biomaterials Unit, International Center for Materials Nanoarchitectonics (MANA), National Institute for Materials Science (NIMS).
Chemical & Pharmaceutical Bulletin
|May 3, 2014
Summary
Researchers developed a one-step electrospray method to create solid collagen nanoparticles for drug delivery. This technique overcomes challenges in solidifying collagen, enabling its use in pulmonary and oral administration.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Drug Delivery Systems
Background:
- Collagen offers excellent biocompatibility and biodegradability for drug delivery.
- Creating solid collagen nanoparticles for pulmonary and oral delivery is challenging.
Purpose of the Study:
- To develop a facile method for producing solid collagen nanoparticles.
- To demonstrate the utility of these nanoparticles as drug carriers.
Main Methods:
- One-step electrospray deposition under ambient conditions.
- Utilizing salts to induce structural perturbation and increase solution conductivity.
- Coaxial spray technique for drug incorporation.
- Cross-linking for controlled drug release.
Main Results:
- Electrospraying collagen solutions yielded solid nanoparticles, not aggregates or nanofibers.
- Theophylline was successfully incorporated as a model drug.
- Controlled release of theophylline was achieved through collagen cross-linking.
Conclusions:
- Electrospray deposition is an effective method for producing solid collagen nanoparticles.
- These nanoparticles show potential as carriers for pulmonary and oral drug delivery.
- The method offers a promising route for advanced biomaterial fabrication.
