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Understanding the influence of the tumor microenvironment on macrophage responses to CD40 agonists
Nadia Luheshi1, Gareth Davies1, James Legg1
1MedImmune Ltd.; Cambridge, UK.
Oncoimmunology
|May 3, 2014
Abstract:
Both TH1 and TH2 cytokines influence the antitumor functions of macrophages. We have recently shown that interferon γ (IFNγ) licenses the antineoplastic functions of CD40 ligand (CD40L)-stimulated macrophages more efficiently than interleukin (IL)-4 and IL-13. The presence of a TH1 and TH2 skewed tumor microenvironment may therefore influence therapeutic responses to CD40 agonists, agents that are showing promise in preliminary clinical trials.

