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Screening mammography benefit controversies: sorting the evidence
1Department of Radiological Sciences, University of California Irvine Medical Center, 101 City Drive South, Orange, CA 92869-3298, USA.
Radiologic Clinics of North America
|May 6, 2014
Summary
Annual breast cancer screening for women aged 40 and older significantly reduces mortality by 30-50%. Guidelines recommend annual screening from age 40 with no upper age limit for women with a life expectancy of at least 5 years.
Area of Science:
- Oncology
- Radiology
- Preventive Medicine
Background:
- Clinical studies confirm significant reductions in breast cancer mortality with screening.
- Screening guidelines must consider age-related factors like cancer growth rates, incidence, life expectancy, and comorbidities.
Purpose of the Study:
- To summarize current recommendations for breast cancer screening in women.
- To highlight the evidence supporting early and continued screening.
Main Methods:
- Review of numerous clinical studies on breast cancer screening efficacy.
- Analysis of factors influencing screening recommendations across different age groups.
Main Results:
- Screening women aged 40 and older reduces breast cancer mortality by 30% to 50%.
- Recommendations are based on balancing benefits against factors like cancer biology and patient health.
Conclusions:
- Annual screening is recommended for women starting at age 40.
- Screening should continue indefinitely for women with a life expectancy of at least 5 years and no significant comorbidities.
