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How pervasive are circadian oscillations?

V R Patel1, K Eckel-Mahan2, P Sassone-Corsi3

  • 1Department of Computer Science, University of California - Irvine, Irvine, CA 92697, USA; Institute for Genomics and Bioinformatics, University of California - Irvine, Irvine, CA 92697, USA.

Trends in Cell Biology
|May 6, 2014
PubMed
Summary
This summary is machine-generated.

Biological systems rely on circadian oscillations for daily coordination. Recent studies reveal cells can select specific genes and metabolites for these rhythms, influenced by genetics, environment, and diet.

Keywords:
circadian metabolomecircadian rhythmscircadian transcriptomeclockcoupled oscillatorsoscillatory patterns

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Area of Science:

  • Chronobiology
  • Molecular Biology
  • Systems Biology

Background:

  • Circadian rhythms are fundamental to physiological and behavioral processes in living organisms.
  • Historically, circadian control was attributed to a central master clock.
  • Emerging evidence indicates widespread potential for circadian oscillations at the cellular level.

Purpose of the Study:

  • To investigate the cellular basis of circadian rhythm selection.
  • To understand how genetic, environmental, and dietary factors influence cellular circadian output.

Main Methods:

  • Utilized high-throughput experimental approaches.
  • Analyzed gene and metabolite expression patterns.
  • Investigated cellular reprogramming in response to varying conditions.

Main Results:

  • Identified a broad repertoire of potential circadian oscillators within cells.
  • Demonstrated that cells actively select a subset of these oscillators.
  • Showcased the influence of genetic, environmental, and dietary factors on this selection process.

Conclusions:

  • Cellular circadian rhythms are more dynamic and adaptable than previously thought.
  • Individual cells possess the capacity to fine-tune their molecular timing.
  • Environmental and internal factors play a crucial role in shaping cellular circadian profiles.