Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

1.7K
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
1.7K
Coronary Artery Disease V: Interprofessional Care01:27

Coronary Artery Disease V: Interprofessional Care

444
Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
444
Antianginal Drugs: Calcium Channel Blockers and Ranolazine01:25

Antianginal Drugs: Calcium Channel Blockers and Ranolazine

1.9K
Angina pectoris, a primary symptom of ischemic heart disease, requires careful pharmacological interventions. In this context, calcium channel blockers (CCBs) and ranolazine have emerged as crucial pharmacotherapeutic agents, providing deep insights into the complexities of angina management.
CCBs, a diverse class that includes dihydropyridines (nifedipine) and diphenylalkylamines (verapamil and diltiazem), exert their effect by blocking calcium channels in cardiac and smooth muscle cells. This...
1.9K
Antihypertensive Drugs: Action of Calcium Channel Blockers01:18

Antihypertensive Drugs: Action of Calcium Channel Blockers

2.4K
Calcium ions are essential to contract smooth muscle cells in blood vessels. They enter these cells through voltage-dependent calcium channels, specifically L-type calcium channels in the cell membrane. These L-type calcium channels are integral to the excitation-contraction coupling process in smooth muscle. When a stimulus is received by smooth muscle cells, their membrane depolarizes. This alteration in membrane potential instigates the opening of L-type calcium channels. As a result,...
2.4K
Antiarrhythmic Drugs: Class IV Agents as Calcium Channel Blockers01:20

Antiarrhythmic Drugs: Class IV Agents as Calcium Channel Blockers

2.8K
Class IV antiarrhythmic drugs, such as verapamil and diltiazem, block calcium channels. They primarily affect the heart, slowing the conduction in calcium-dependent tissues like the SA and AV nodes. These drugs manage reentrant supraventricular tachycardia (SVT) and reduce ventricular rate in atrial flutter/fibrillation.
Verapamil, a calcium channel blocker, inhibits calcium movement across myocardial cell membranes and vascular smooth muscle. This results in the dilation of coronary and...
2.8K
Antihypertensive Drugs: Direct Renin Inhibitors01:25

Antihypertensive Drugs: Direct Renin Inhibitors

1.9K
The renin-angiotensin-aldosterone system (RAAS) is an intricate physiological pathway involving numerous enzymes and hormones, including renin, angiotensin-converting enzyme (ACE), angiotensin I and II, and aldosterone. Imbalances within this system increase the production of angiotensin II and aldosterone. Increased angiotensin II levels promote vasoconstriction and blood pressure elevation. Concurrently, higher aldosterone levels stimulate sodium and water reabsorption in the kidneys,...
1.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

RETRACTED: Nazir et al. Curative Effect of Catechin Isolated from <i>Elaeagnus Umbellata</i> Thunb. Berries for Diabetes and Related Complications in Streptozotocin-Induced Diabetic Rats Model. <i>Molecules</i> 2021, <i>26</i>, 137.

Molecules (Basel, Switzerland)·2026
Same author

Dichlorophthalic Anhydride Derivatives as Anti-Apoptotic and Antiproliferative Agents by Multi-Targeted Mechanism: Biological Evaluation and Molecular Docking Studies.

Journal of biochemical and molecular toxicology·2026
Same author

What a Difference a Water Molecule Makes-A Combined Experimental/Theoretical Study on 2,3,5-triphenyl-2<i>H</i>-tetrazol-3-ium Chloride Hydrate in Solution and the Solid-State.

Molecules (Basel, Switzerland)·2026
Same author

Light-mediated CO release from a tricarbonyl manganese(i) complex with a bidentate quinoxaline ligand.

RSC advances·2025
Same author

Cytotoxicity of Pd(ii) and Pt(ii) complexes of 2',6'-di(thiazol-2-yl)-2,4'-bipyridine: insights into the mode of cell death and cell cycle arrest.

RSC advances·2025
Same author

Characterization, Antibacterial Evaluation and Computational Study of Synthesized 4,5-bis(Hydroxymethyl)-2-Methylpyridin-3-ol Tetraphenylborate Ion-Pair Complex.

ChemistryOpen·2025
Same journal

Preface.

Profiles of drug substances, excipients, and related methodology·2026
Same journal

Rosuvastatin calcium: A comprehensive profile.

Profiles of drug substances, excipients, and related methodology·2026
Same journal

Kinetic exclusion assay technology: Theory, experimental aspects, and applications in concentration measurements across diverse fields.

Profiles of drug substances, excipients, and related methodology·2026
Same journal

Drugs and polymer based local delivery systems in the treatment of periodontal diseases.

Profiles of drug substances, excipients, and related methodology·2026
Same journal

Perindopril: A comprehensive profile.

Profiles of drug substances, excipients, and related methodology·2026
Same journal

Ferulic acid: A comprehensive profile.

Profiles of drug substances, excipients, and related methodology·2026
See all related articles

Related Experiment Video

Updated: Apr 30, 2026

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

14.8K

Pravastatin sodium.

Abdullah A Al-Badr1, Gamal A E Mostafa1

  • 1Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh, Kingdom of Saudi Arabia.

Profiles of Drug Substances, Excipients, and Related Methodology
|May 6, 2014
PubMed
Summary
This summary is machine-generated.

Pravastatin sodium, a lipid-regulating drug, is detailed in this profile, covering its properties, synthesis, and analytical methods. This comprehensive overview aids in understanding and analyzing this important HMG-CoA reductase inhibitor.

Keywords:
DescriptionMetabolismMethod of analysisPharmacokineticsPhysical characteristicsPravastatin sodiumReviewsSpectral propertiesStabilitySynthesisUses

More Related Videos

In vivo Near Infrared Fluorescence NIRF Intravascular Molecular Imaging of Inflammatory Plaque, a Multimodal Approach to Imaging of Atherosclerosis
09:43

In vivo Near Infrared Fluorescence NIRF Intravascular Molecular Imaging of Inflammatory Plaque, a Multimodal Approach to Imaging of Atherosclerosis

Published on: August 4, 2011

17.5K
Thermostabilization, Expression, Purification, and Crystallization of the Human Serotonin Transporter Bound to S-citalopram
12:21

Thermostabilization, Expression, Purification, and Crystallization of the Human Serotonin Transporter Bound to S-citalopram

Published on: November 27, 2016

15.4K

Related Experiment Videos

Last Updated: Apr 30, 2026

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

14.8K
In vivo Near Infrared Fluorescence NIRF Intravascular Molecular Imaging of Inflammatory Plaque, a Multimodal Approach to Imaging of Atherosclerosis
09:43

In vivo Near Infrared Fluorescence NIRF Intravascular Molecular Imaging of Inflammatory Plaque, a Multimodal Approach to Imaging of Atherosclerosis

Published on: August 4, 2011

17.5K
Thermostabilization, Expression, Purification, and Crystallization of the Human Serotonin Transporter Bound to S-citalopram
12:21

Thermostabilization, Expression, Purification, and Crystallization of the Human Serotonin Transporter Bound to S-citalopram

Published on: November 27, 2016

15.4K

Area of Science:

  • Pharmaceutical Chemistry
  • Medicinal Chemistry

Background:

  • Pravastatin sodium is a key HMG-CoA reductase inhibitor used for lipid regulation.
  • Understanding its physicochemical properties and synthesis is crucial for pharmaceutical development.

Purpose of the Study:

  • To provide a comprehensive profile of Pravastatin sodium.
  • To detail its nomenclature, formulae, elemental composition, solubility, appearance, and partition coefficient.
  • To review reported synthesis methods and characterization techniques.

Main Methods:

  • Characterization using X-ray powder diffraction, thermal methods, melting point, and differential scanning calorimetry.
  • Spectroscopic analysis including UV, vibrational, NMR, and mass spectrometry.
  • Overview of compendial and other analytical methods: spectrophotometric, electrochemical, polarographic, voltammetric, chromatographic, and immunoassay.

Main Results:

  • Detailed description of Pravastatin sodium's physical and chemical properties.
  • Compilation of various synthesis routes and analytical methodologies.
  • Inclusion of pharmacokinetic, metabolism, and stability data.

Conclusions:

  • This profile offers a thorough resource on Pravastatin sodium manufacturing, characterization, and analysis.
  • The extensive reference list supports further research in this area.
  • Provides a foundational understanding for pharmaceutical scientists and researchers.