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Lipid shedding from single oscillating microbubbles.

Ying Luan1, Guillaume Lajoinie2, Erik Gelderblom2

  • 1Biomedical Engineering Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands.

Ultrasound in Medicine & Biology
|May 7, 2014
PubMed
Summary
This summary is machine-generated.

Researchers optically characterized lipid shedding from microbubbles under ultrasound. They found lipid detachment occurs rapidly, within a few cycles, and is controllable above a 30% oscillation amplitude threshold, crucial for ultrasound imaging and drug delivery.

Keywords:
Controlled drug deliveryFluorescence imagingHigh-speed imagingLipid sheddingMicrobubblesMicrostreaming

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Area of Science:

  • Biomedical engineering
  • Acoustic physics
  • Materials science

Background:

  • Lipid-coated microbubbles are vital for ultrasound imaging and drug delivery.
  • Understanding lipid shedding dynamics is key for optimizing microbubble stability and therapeutic applications.
  • Current knowledge on lipid shedding under acoustic excitation is limited.

Purpose of the Study:

  • To optically characterize the dynamics of lipid shedding from individual microbubbles under ultrasound.
  • To investigate the influence of acoustic parameters on the onset of lipid shedding.
  • To determine the threshold for controlled lipid shedding.

Main Methods:

  • Utilized high-speed fluorescence imaging at 150,000 frames per second to observe lipid detachment.
  • Employed an ultrafast framing camera at 10 million frames per second to record bubble oscillation amplitude.
  • Applied single ultrasound bursts with varying cycles, frequency, and acoustic pressure.

Main Results:

  • Lipid shedding was observed within the initial cycles of ultrasound application.
  • Detached lipids exhibited both in-plane and out-of-plane transport.
  • A reproducible threshold for lipid shedding was identified at a relative bubble oscillation amplitude exceeding 30%.

Conclusions:

  • Lipid shedding from microbubbles under ultrasound is a rapid and controllable process.
  • The identified shedding threshold provides a basis for optimizing ultrasound-triggered drug delivery.
  • This study offers critical insights into microbubble behavior for advanced biomedical applications.