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Hypercortisolism in obesity-associated hypertension

Amy G Varughese1, Oksana Nimkevych, Gabriel I Uwaifo

  • 1Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, Louisiana State University Health Sciences Center (LSUHSC), 1542 Tulane Avenue, New Orleans, LA, 70112, USA, avarug@lsuhsc.edu.

Current Hypertension Reports
|May 8, 2014
PubMed

Insights

Obesity-related hypertension, particularly when linked to hypercortisolism, requires specific management. Treatments targeting the renin-angiotensin-aldosterone system and cortisol activity show promise for this distinct hypertension subtype.

Area of Science:

  • Endocrinology
  • Cardiology
  • Metabolic Disorders

Background:

  • Obesity is a global health issue linked to increased cardiovascular disease risk.
  • Hypertension is the most common comorbidity in obesity, significantly raising cardiovascular risk.
  • Hypercortisolism, including various Cushing's syndromes, is increasingly recognized as a key factor in obesity-induced hypertension.

Purpose of the Study:

  • To provide a comprehensive review of glucocorticoid-mediated obesity hypertension.
  • To explore the epidemiology, etiopathogenesis, and management strategies for this condition.

Main Methods:

  • Literature review synthesizing current data on hypercortisolism and hypertension in obesity.
  • Analysis of diagnostic considerations and therapeutic options.

Main Results:

  • Hypercortisolism is an important consideration in managing obesity hypertension resistant to standard treatments.
  • Antihypertensives targeting the renin-angiotensin-aldosterone system demonstrate efficacy in hypercortisolism-mediated obesity hypertension.
  • Interventions aimed at reducing cortisol production or blocking its action are beneficial.

Conclusions:

  • Glucocorticoid excess plays a significant role in a subtype of obesity hypertension.
  • Effective management involves addressing hypercortisolism alongside conventional hypertension therapies.
  • Further research into specific therapeutic strategies for hypercortisolism-mediated obesity hypertension is warranted.

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