Determination of early urinary renal injury markers in obese children

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Nilufer Goknar1, Faruk Oktem, Ilker Tolga Ozgen

  • 1Department of Pediatric Nephrology, Bezmialem Vakif University Medical Faculty, Istanbul, Turkey.

Pediatric Nephrology (Berlin, Germany)
|May 8, 2014
PubMed

Insights

Childhood obesity is linked to early kidney damage. Urinary N-acetyl-beta-D-glucosaminidase (NAG) and kidney injury molecule-1 (KIM-1) can help screen for this renal damage in obese children.

Area of Science:

  • Pediatric Nephrology
  • Metabolic Disorders
  • Biomarker Discovery

Background:

  • Childhood obesity is a growing global health concern.
  • Obesity is associated with increased risk of comorbidities and potential organ damage.
  • Early detection of renal effects in obese children is crucial.

Purpose of the Study:

  • To investigate urinary renal injury markers in pediatric obesity.
  • To determine the association between obesity, its comorbidities, and renal damage.
  • To evaluate specific markers for early renal damage detection.

Main Methods:

  • Study included 84 obese children and 64 healthy controls.
  • Urinary analysis for N-acetyl-beta-D-glucosaminidase (NAG), neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), and microalbumin.
  • Assessment of marker associations with hypertension, impaired glucose tolerance, and insulin resistance.

Main Results:

  • Obese children showed significantly higher urinary NAG and KIM-1 levels compared to controls.
  • No significant difference in urinary NGAL levels was observed between obese and lean subjects.
  • Urinary renal injury markers did not show statistically significant differences concerning comorbidities like hypertension, impaired glucose tolerance, or insulin resistance.

Conclusions:

  • Urinary NAG and KIM-1 show promise as early screening tools for renal damage in obese children.
  • These markers may aid in the early identification of kidney complications associated with pediatric obesity.
  • Further research can validate these findings for clinical application.
Abstract

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