Related Experiment Video

Updated: Apr 30, 2026

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice
07:25

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice

Published on: September 25, 2019

6.6K

Frontiers in the treatment of hepatitis C virus infection

Joseph Ahn1, Steven L Flamm1

  • 1Dr Ahn is an associate professor of medicine at the Oregon Health & Science University in Portland, Oregon. Dr Flamm is a professor of medicine at the Northwestern University Feinberg School of Medicine in Chicago, Illinois.

Gastroenterology & Hepatology
|May 8, 2014
PubMed

Insights

Hepatitis C virus (HCV) screening is underutilized despite available diagnostics. New all-oral medications are transforming HCV treatment, offering hope for widespread cure and improved liver health outcomes.

Area of Science:

  • Hepatology
  • Infectious Diseases
  • Public Health

Background:

  • Chronic hepatitis C virus (HCV) infection is a leading cause of liver disease and transplantation in the US.
  • Despite over 20 years of diagnostic availability, a significant portion of HCV cases remain undiagnosed.
  • Recent changes in screening recommendations by the CDC reflect the need for increased diagnosis.

Purpose of the Study:

  • To review current screening recommendations for HCV infection.
  • To outline the standard of care for HCV treatment.
  • To highlight emerging therapies that are poised to revolutionize HCV management.

Main Methods:

  • Review of current literature on HCV screening guidelines.
  • Analysis of recent treatment advancements and approved medications for HCV.
  • Examination of investigational agents in the HCV drug development pipeline.

Main Results:

  • Updated CDC screening recommendations aim to increase HCV diagnosis rates.
  • Newer antiviral medications, including sofosbuvir and simeprevir, have significantly improved treatment efficacy.
  • A rapid expansion of diverse medication classes is anticipated, leading to all-oral regimens for HCV genotype 1.

Conclusions:

  • Increased HCV screening is crucial for identifying undiagnosed infections.
  • Recent therapeutic advances offer highly effective treatment options for HCV.
  • The future of HCV treatment involves all-oral regimens, promising a paradigm shift in patient care and outcomes.

Keywords:
Hepatitis C virusNS3/4A protease inhibitorsNS5A inhibitorsNS5B inhibitorsdirect-acting antiviral therapyinterferonsofosbuvir

More Related Videos

A Protocol for Analyzing Hepatitis C Virus Replication13:04

A Protocol for Analyzing Hepatitis C Virus Replication

Published on: June 26, 2014

23.7K
A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target11:34

A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target

Published on: May 10, 2022

2.2K

Related Concept Videos

Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver.
86
Viral Hepatitis I: Introduction01:28

Viral Hepatitis I: Introduction

Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion...
25
Retrovirus Life Cycles01:10

Retrovirus Life Cycles

Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
43.0K
Inhibitors of Viral Protein Synthesis01:30

Inhibitors of Viral Protein Synthesis

Protein synthesis is indispensable for viral replication, as viruses lack the cellular machinery required for this process and must hijack the host's translational apparatus. In response, host cells deploy a critical innate immune defense involving interferons, specialized cytokines that play a central role in inhibiting viral propagation.Upon viral detection, infected cells release interferons that bind to receptors on adjacent uninfected cells, activating the JAK-STAT signaling pathway and...
58
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow01:26

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...
382
Cirrhosis I: Introduction01:23

Cirrhosis I: Introduction

Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...
28