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Updated: Apr 30, 2026
08:49
A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
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Melanoma m1: diagnosis and therapy
Marco Rastrelli1, Saveria Tropea, Jacopo Pigozzo
1Melanoma and Sarcoma Unit, Veneto Institute of Oncology IOV-IRCCS Padova, Italy. marco.rastrelli@ioveneto.it.
In Vivo (Athens, Greece)
|May 13, 2014
Summary
This review covers metastatic melanoma, detailing its progression, diagnosis, and prognostic factors. Recent advancements in targeted therapies and biological treatments like ipilimumab have significantly improved outcomes for stage IV melanoma patients.
Area of Science:
- Oncology
- Dermatology
- Cancer Research
Background:
- Metastatic melanoma is a complex cancer with diverse progression models.
- Understanding its epidemiology and molecular pathogenesis is crucial for effective treatment.
Purpose of the Study:
- To provide a comprehensive review of metastatic melanoma.
- To highlight recent advancements in diagnosis and treatment strategies.
Main Methods:
- Literature review of epidemiology, pathogenesis, diagnosis, prognostic factors, and treatment of metastatic melanoma.
- Analysis of sequential and non-linear melanoma development models.
- Examination of molecular disorders in melanoma progression.
Main Results:
- Key prognostic factors include surgical resectability, metastasis characteristics, and serum lactate dehydrogenase levels.
- Surgical treatment, radiotherapy, chemotherapy, and targeted therapies are discussed.
- Newer agents like ipilimumab and vemurafenib have advanced stage IV melanoma treatment.
Conclusions:
- Metastatic melanoma requires a multi-faceted approach to management.
- Recent therapeutic innovations offer improved prospects for advanced-stage patients.
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