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The protective arms of the renin-angiontensin system in stroke

Claudia A McCarthy1, Lachlan J Facey, Robert E Widdop

  • 1Department of Pharmacology, Monash University, Clayton, Victoria, 3800, Australia.

Current Hypertension Reports
|May 13, 2014
PubMed

Insights

Activating protective renin-angiotensin system (RAS) pathways, including AT2 and Mas receptors, offers neuroprotection against stroke. These strategies complement existing treatments by targeting stroke mechanisms.

Area of Science:

  • Cardiovascular Research
  • Neuroscience
  • Pharmacology

Background:

  • The renin-angiotensin system (RAS) plays a critical role in cardiovascular regulation.
  • AT1 receptor overactivity is linked to cardiovascular pathologies.
  • Protective RAS arms, including AT2 and Mas receptors, counterbalance AT1 effects.

Purpose of the Study:

  • To review recent evidence on neuroprotective pathways in stroke.
  • To explore complementary therapeutic strategies to AT1 receptor blockade.
  • To highlight novel targets within the RAS for stroke treatment.

Main Methods:

  • Review of preclinical stroke models.
  • Analysis of studies targeting AT2 receptor stimulation.
  • Evaluation of research on Mas receptor stimulation.
  • Assessment of insulin-regulated aminopeptidase blockade efficacy.

Main Results:

  • AT2 receptor stimulation demonstrates significant neuroprotective effects in stroke models.
  • Mas receptor stimulation shows promise in mitigating stroke-induced damage.
  • Insulin-regulated aminopeptidase blockade exhibits neuroprotective potential.
  • These pathways offer complementary benefits to AT1 receptor blockade.

Conclusions:

  • Targeting AT2, Mas receptors, and insulin-regulated aminopeptidase offers novel therapeutic avenues for stroke.
  • These strategies present translational opportunities for stroke treatment.
  • Activating protective RAS pathways can be a valuable addition to stroke management.

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