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Updated: Apr 29, 2026

A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection
Published on: October 5, 2015
Functional activity of Th-17 lymphocytes in pulmonary tuberculosis
T E Kononova1, O I Urazova, V V Novitskii
1Department of Pathophysiology, Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia, kononova.te@gmail.com.
Abstract:
Increased content of CD4(+)CD161(+)IL-17A(+) Th17 lymphocytes in the peripheral blood was found in patients with pulmonary tuberculosis irrespective of the clinical form (infiltrative, disseminated) and variant of the disease (drug-sensitive, drug-resistant). The elevated content of Th17 cells in pulmonary tuberculosis is associated with hypersecretion of Th17-associated cytokines IL-17A and IL-22 in vitro that was most pronounced (in case of IL-17A) in patients with disseminated pulmonary tuberculosis.
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