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Age-related features of Cytoflavin effectiveness during experimental myocardial ischemia
N I Zhernakova1, T V Gorbach, O V Romashchenko
1Belgorod State National Research University, Belgorod, Russia.
Bulletin of Experimental Biology and Medicine
|May 15, 2014
Abstract:
Administration of Cytoflavin to young rats with experimental myocardial ischemia was followed by activation of mitochondrial enzymes and significant accumulation of ATP in the myocardium and blood plasma, but did not modulate the stability of cardiomyocyte membranes and signs of hypoxia. Cytoflavin increased the severity of metabolic disorders and depleted the energy reserves of cells in old rats with myocardial ischemia.
