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A novel fully water-soluble Cu(I) probe for fluorescence live cell imaging
Maria Laura Giuffrida1, Enrico Rizzarelli, Gaetano A Tomaselli
1Institute of Biostructure and Bioimaging, National Research Council, Viale Andrea Doria, Catania 95125, Italy.
Chemical Communications (Cambridge, England)
|May 16, 2014
Abstract:
A new Cu(I) probe (OBEP-CS1), bearing an alkyl-pyridinium moiety to get complete water solubility, was synthesized. Fluorescence titrations support copper binding and high selectivity in a water solution whereas formation of aggregates was excluded by DOSY experiments. The detection capability for intracellular Cu(I), especially localized in mitochondria, was demonstrated in differentiated neuroblastoma cells by confocal microscopy.
