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Related Concept Videos

Obesity01:24

Obesity

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The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
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Drug Dosing: Obese Patients01:21

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In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
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Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

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Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
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Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

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Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
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Hypodermis01:02

Hypodermis

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The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...
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Binge Eating Disorders01:23

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Binge eating disorder is a significant mental health condition characterized by recurrent episodes of excessive food consumption within a short period, accompanied by a perceived loss of control over eating behavior. Unlike occasional overeating, binge eating disorder is marked by distressing emotions such as guilt, shame, and anxiety following binge episodes. The disorder affects individuals across different ages and backgrounds, with profound implications for physical and psychological...
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Multidisciplinary Approach to Obesity Management: A Case Report
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A quick look at obesity; the enemy within.

Parichehr Hassanzadeh1

  • 1Research Institute for Gastroenterology and Liver Disease, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

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|May 17, 2014
PubMed
Summary
This summary is machine-generated.

Obesity is a growing global health issue linked to many diseases. Lifestyle changes and exploring neurotrophic factors offer promising avenues for managing this complex condition, as current treatments have limitations.

Keywords:
BrainChemical contributorsObesityTherapeutic approaches

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Area of Science:

  • Metabolic research
  • Neuroscience
  • Public health

Background:

  • Obesity prevalence is increasing globally, posing significant health risks due to associated comorbidities.
  • Current obesity treatments like pharmacotherapy, bariatric surgery, and gene therapy have notable drawbacks, including side effects, poor patient adherence, and limited long-term efficacy.
  • The complex and multifactorial nature of obesity presents ongoing challenges in effective management.

Purpose of the Study:

  • To highlight the limitations of existing obesity therapies.
  • To emphasize the potential of lifestyle modifications in obesity management.
  • To discuss the emerging research on neurotrophic factors and their role in targeted obesity pharmacology.

Main Methods:

  • Literature review of current obesity treatments and their limitations.
  • Exploration of the role of lifestyle factors in obesity.
  • Review of recent research on neurotrophic factors and their metabotrophic potential.

Main Results:

  • Current pharmacological and surgical interventions for obesity are often limited by side effects, compliance issues, or transient effectiveness.
  • Lifestyle modifications represent a crucial, yet often underexplored, component in managing obesity.
  • Neurotrophic factors are emerging as a significant area of research for targeted pharmacological approaches to obesity.

Conclusions:

  • Effective obesity management requires a multifaceted approach, considering both lifestyle interventions and novel pharmacological strategies.
  • Further research into neurotrophic factors holds promise for developing more effective and sustainable obesity treatments.
  • Addressing the complexity of obesity necessitates continued investigation into diverse therapeutic avenues.